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Similar to murine TLS and human TLS in nephrectomized kidneys (Figure 2), 4-HNE and 8-OHdG accumulation was also observed within TLS of IgA nephropathy patients (Supplemental Figure 15)

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The effects of TGF- signaling in cell proliferation, 15,16 cell differentiation, 17,18 embryonic development, 19 wound healing, 20 immune regulation, 21,22 tissue fibrosis, 23,24 and tumor development 25,26 have been studied shortly after the discovery of the cytokine